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＜Original Papers＞
A novel VCP modulator KUS121 exerts renoprotective effects in ischemia-reperfusion injury with retaining ATP and restoring ERAD-processing capacity.
Hata Y, Date R, Fujimoto D, Ikeda HO, Umemoto S, Kanki T, Nishiguchi Y, Mizumoto T, Hayata M, Kakizoe Y, Izumi Y, Kakizuka A, Mukoyama M, Kuwabara T.
Am J Physiol Renal Physiol. 2022 May 1;322(5):F577-F586.
KUS121 attenuates the progression of monosodium iodoacetate-induced osteoarthritis in rats.
Iwai S, Ikeda HO, Mera H, Nishitani K, Saito M, Tsujikawa A, Kakizuka A.
Sci Rep. 2021 Aug 2;11(1):15651.
VCP relocalization limits mitochondrial activity, GSH depletion and ferroptosis during starvation in PC3 prostate cancer cells.
Ogor P, Yoshida T, Koike M, Kakizuka A.
Genes Cells. 2021 Aug;26(8):570-582.
Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model.
Hasegawa T, Ikeda HO, Iwai S, Sasaoka N, Kakizuka A, Tsujikawa A.
Sci Rep. 2020 Dec 10;10(1):21653.
A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis.
Saito M, Nishitani K, Ikeda HO, Yoshida S, Iwai S, Ji X, Nakahata A, Ito A, Nakamura S, Kuriyama S, Yoshitomi H, Murata K, Aoyama T, Ito H, Kuroki H, Kakizuka A, Matsuda S.
Sci Rep. 2020 Nov 27;10(1):20787.
Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis.
Imamura H, Sakamoto S, Yoshida T, Matsui Y, Penuela S, Laird DW, Mizukami S, Kikuchi K, Kakizuka A.
Elife. 2020 Oct 14;9:e61960.
Effect of VCP modulators on gene expression profiles of retinal ganglion cells in an acute injury mouse model.
Hasegawa T, Ikeda HO, Gotoh N, Iida K, Iwai S, Nakano N, Kakizuka A, Tsujikawa A.
Sci Rep. 2020 Mar 6;10(1):4251.
Safety and effectiveness of a novel neuroprotectant, KUS121, in patients with non-arteritic central retinal artery occlusion: An open-label, non-randomized, first-in-humans, phase 1/2 trial.
Ikeda HO, Muraoka Y, Hata M, Sumi E, Ikeda T, Nakagawa T, Abe H, Tada H, Morita S, Kakizuka A, Yoshimura N, Tsujikawa A.
PLoS One. 2020 Feb 13;15(2):e0229068.
Genetic screening for potassium channel mutations in Japanese autosomal dominant spinocerebellar ataxia.
Tada Y, Kume K, Matsuda Y, Kurashige T, Kanaya Y, Ohsawa R, Morino H, Tabu H, Kaneko S, Suenaga T, Kakizuka A, Kawakami H.
J Hum Genet. 2020 Apr;65(4):363-369.
OLIVe: A Genetically Encoded Fluorescent Biosensor for Quantitative Imaging of Branched-Chain Amino Acid Levels inside Single Living Cells.
Yoshida T, Nakajima H, Takahashi S, Kakizuka A, Imamura H.
ACS Sens. 2019 Dec 27;4(12):3333-3342.
Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance.
Nie X, Kitaoka S, Shinohara M, Kakizuka A, Narumiya S, Furuyashiki T.
Sci Rep. 2019 Nov 26;9(1):17548.
Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction.
Ide Y, Horie T, Saito N, Watanabe S, Otani C, Miyasaka Y, Kuwabara Y, Nishino T, Nakao T, Nishiga M, Nishi H, Nakashima Y, Nakazeki F, Koyama S, Kimura M, Tsuji S, Rodriguez RR, Xu S, Yamasaki T, Watanabe T, Yamamoto M, Yanagita M, Kimura T, Kakizuka A, Ono K.
JACC Basic Transl Sci. 2019 Oct 28;4(6):701-714.
Ellagic acid, extracted from Sanguisorba officinalis, induces G1 arrest by modulating PTEN activity in B16F10 melanoma cells.
Tan YH, Shudo T, Yoshida T, Sugiyama Y, Si JY, Tsukano C, Takemoto Y, Kakizuka A.
Genes Cells. 2019 Nov;24(11):688-704.
KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion.
Kinoshita H, Maki T, Yasuda K, Kishida N, Sasaoka N, Takagi Y, Kakizuka A, Takahashi R.
Sci Rep. 2019 Aug 8;9(1):11519.
Emodin, as a mitochondrial uncoupler, induces strong decreases in adenosine triphosphate (ATP) levels and proliferation of B16F10 cells, owing to their poor glycolytic reserve.
Sugiyama Y, Shudo T, Hosokawa S, Watanabe A, Nakano M, Kakizuka A.
Genes Cells. 2019 Aug;24(8):569-584.
PPARα-Mediated Positive-Feedback Loop Contributes to Cold Exposure Memory.
Alfaqaan S, Yoshida T, Imamura H, Tsukano C, Takemoto Y, Kakizuka A.
Sci Rep. 2019 Mar 14;9(1):4538
A Trace Amount of Galactose, a Major Component of Milk Sugar, Allows Maturation of Glycoproteins during Sugar Starvation.
Sasaoka N, Imamura H, Kakizuka A.
iScience. 2018 Dec 21;10:211-221
In vivo targeted single-nucleotide editing in zebrafish.
Tanaka S, Yoshioka S, Nishida K, Hosokawa H, Kakizuka A, Maegawa S.
Sci Rep. 2018 Jul 30;8(1):11423
The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation.
Nie X, Kitaoka S, Tanaka K, Segi-Nishida E, Imoto Y, Ogawa A, Nakano F, Tomohiro A, Nakayama K, Taniguchi M, Mimori-Kiyosue Y, Kakizuka A, Narumiya S, Furuyashiki T.
Nuron. 2018 Aug 8;99(3):464-479.e7.
KUS121, an ATP regulator, mitigates chorioretinal pathologies in animal models of age-related macular degeneration.
Muraoka Y, Iida Y, Ikeda HO, Iwai S, Hata M, Iwata T, Nakayama M, Shimozawa N, Katakai Y, Kakizuka A, Yoshimura N, Tsujikawa A.
Heliyon. May 14;4(5):e00624.
Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma.
Hasegawa T, Ikeda HO, Iwai S, Muraoka Y, Tsuruyama T, Okamoto-Furuta K, Kohda H, Kakizuka A, Yoshimura N.
Heliyon. 2018 Mar 1;4(2):e00544.
Analysis of mitochondrial function in human induced pluripotent stem cells from patients with mitochondrial diabetes due to the A3243G mutation.
Matsubara M, Kanda H, Imamura H, Inoue M, Noguchi M, Hosoda K, Kakizuka A, Nakao K.
Sci Rep. 2018 Jan 17;8(1):949.
A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs.
Konagaya Y, Terai K, Hirao Y, Takakura K, Imajo M, Kamioka Y, Sasaoka N, Kakizuka A, Sumiyama K, Asano T, Matsuda M.
Cell Rep. 2017 Nov 28;21(9):2628-2638.
ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease.
Nakano M, Imamura H, Sasaoka N, Yamamoto M, Uemura N, Shudo T, Fuchigami T, Takahashi R, Kakizuka A.
EBioMedicine. 2017 Aug;22:225-241.
KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress.
Hata M, Ikeda HO, Kikkawa C, Iwai S, Muraoka Y, Hasegawa T, Kakizuka A, Yoshimura N.
Sci Rep. 2016 Dec 21;6:39618.
BTeam, a Novel BRET-based Biosensor for the Accurate Quantification of ATP Concentration within Living Cells.
Yoshida T, Kakizuka A, Imamura H.
EBioMedicine. 2017 Aug;22:225-241.
Neuoroprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration.
Hasegawa T, Muraoka Y, Ikeda HO, Tsuruyama T, Kondo M, Terasaki H, Kakizuka A, Yoshimura N.
Sci Rep. 2016 Aug 9;6:31184.
Neuroprotective effects of VCP modulators in mouse models of glaucoma.
Nakano N, Ikeda HO, Hasegawa T, Muraoka Y, Iwai S, Tsuruyama T, Nakano M, Fuchigami T, Shudo T, Kakizuka A, Yoshimura N.
Heliyon. 2016 Apr 19;2(4):e00096.
Coordinated Regulation of TIP60 and Poly(ADP-Ribose) Polymerase 1 in Damaged-Chromatin Dynamics.
Ikura M, Furuya K, Fukuto A, Matsuda R, Adachi J, Matsuda T, Kakizuka A, Ikura T.
Mol Cell Biol. 2016 May 2;36(10):1595-607.
Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor.
Matsuda S, Adachi J, Ihara M, Tanuma N, Shima H, Kakizuka A, Ikura M, Ikura T, Matsuda T.
Nucleic Acids Res. 2016 Jan 29;44(2):636-47.
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＜和文総説＞
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