京都大学 垣塚研究室
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発表論文

2016〜

2011〜2015

2006〜2010

2000〜2005

〜1999
2011〜2015
<Original Papers>

Identification of a New Type of Covalent PPARγ Agonist using a Ligand-Linking Strategy.
Ohtera A, Miyamae Y, Yoshida K, Maejima K, Akita T, Kakizuka A, Irie K, Masuda S, Kambe T, Nagao M.
ACS Chem Biol. 2015 Oct 12.


VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast.
Ohnuma Y, Takata T, Kawawaki J, Yasuda K, Tanaka K, Kimura Y, Kakizuka A.
FEBS Lett. 2015 Feb 27;589(5):576-80.


Diversity in ATP concentrations in a single bacterial cell population revealed by quantitative single-cell imaging.
Yaginuma H, Kawai S, Tabata KV, Tomiyama K, Kakizuka A, Komatsuzaki T, Noji H, Imamura H.
Sci Rep. 2014 Oct 6;4:6522.


Novel VCP modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosa.
Ikeda HO, Sasaoka N, Koike M, Nakano N, Muraoka Y, Toda Y, Fuchigami T, Shudo T, Iwata A, Hori S, Yoshimura N, Kakizuka A.
Sci Rep. 2014 Aug 6;4:5970.


Long-term oral administration of hop flower extracts mitigates Alzheimer phenotypes in mice.
Sasaoka N, Sakamoto M, Kanemori S, Kan M, Tsukano C, Takemoto Y, Kakizuka A.
PLoS One. 2014 Jan 29;9(1):e87185.


Mdm20 stimulates polyQ aggregation via inhibiting autophagy through Akt-Ser473 phosphorylation.
Yasuda K, Ohyama K, Onga K, Kakizuka A, Mori N.
PLoS One. 2013 Dec 16;8(12):e82523.


Glucose-stimulated single pancreatic islets sustain increased cytosolic ATP levels during initial Ca2+ influx and subsequent Ca2+ oscillations.
Tanaka T, Nagashima K, Inagaki N, Kioka H, Takashima S, Fukuoka H, Noji H, Kakizuka A, Imamura H.
J Biol Chem. 2014 Jan 24;289(4):2205-16.


Different dynamic movements of wild-type and pathogenic VCPs and their cofactors to damaged mitochondria in a Parkin-mediated mitochondrial quality control system.
Kimura Y, Fukushi J, Hori S, Matsuda N, Okatsu K, Kakiyama Y, Kawawaki J, Kakizuka A, Tanaka K.
Genes Cells. 2013 Dec;18(12):1131-43.


In vivo fluorescent adenosine 5'-triphosphate (ATP) imaging of Drosophila melanogaster and Caenorhabditis elegans by using a genetically encoded fluorescent ATP biosensor optimized for low temperatures.
Tsuyama T, Kishikawa J, Han YW, Harada Y, Tsubouchi A, Noji H, Kakizuka A, Yokoyama K, Uemura T, Imamura H.
Anal Chem. 2013 Aug 20;85(16):7889-96.


Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells.
Ehrlich AT, Furuyashiki T, Kitaoka S, Kakizuka A, Narumiya S.
Mol Pharmacol. 2013 Sep;84(3):476-86.


VCP Is an integral component of a novel feedback mechanism that controls intracellular localization of catalase and H2O2 Levels.
Murakami K, Ichinohe Y, Koike M, Sasaoka N, Iemura S, Natsume T, Kakizuka A.
PLoS One. 2013;8(2):e56012.


In vitro modeling of paraxial mesodermal progenitors derived from induced pluripotent stem cells.
Sakurai H, Sakaguchi Y, Shoji E, Nishino T, Maki I, Sakai H, Hanaoka K, Kakizuka A, Sehara-Fujisawa A.
PLoS One. 2012;7(10):e47078.


Rescue of growth defects of yeast cdc48 mutants by pathogenic IBMPFD-VCPs.
Takata T, Kimura Y, Ohnuma Y, Kawawaki J, Kakiyama Y, Tanaka K, Kakizuka A.
J Struct Biol. 2012 Aug;179(2):93-103.


Real-time imaging of rabbit retina with retinal degeneration by using spectral-domain optical coherence tomography.
Muraoka Y, Ikeda HO, Nakano N, Hangai M, Toda Y, Okamoto-Furuta K, Kohda H, Kondo M, Terasaki H, Kakizuka A, Yoshimura N.
PLoS One. 2012;7(4):e36135.


Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5.
Ohyama K, Yasuda K, Onga K, Kakizuka A, Mori N.
Gene Expr Patterns. 2012 Jan-Feb;12(1-2):36-45.


Longitudinal and simultaneous imaging of retinal ganglion cells and inner retinal layers in a mouse model of glaucoma induced by N-methyl-D-aspartate.
Nakano N, Ikeda HO, Hangai M, Muraoka Y, Toda Y, Kakizuka A, Yoshimura N.
Invest Ophthalmol Vis Sci. 2011 Nov 11;52(12):8754-62.


Interaction of ataxin-3 with huntingtin-associated protein 1 through Josephin domain.
Takeshita Y, Fujinaga R, Kokubu K, Islam MN, Jahan MR, Yanai A, Kakizuka A, Shinoda K.
Neuroreport. 2011 Mar 30.


<和文総説>

ホップ抽出液のアルツハイマー病発症抑制効果
笹岡紀男、垣塚 彰
BIO INDUSTRY 31:34~39 (2014)


タンパク質の品質管理と神経変性
木村洋子、垣塚 彰
Annual Review 神経206-211 (2014)


神経変性疾患と細胞死
垣塚 彰
細胞死Update-基礎から臨床までを俯瞰して(別冊・医学のあゆみ)97-102.(2014)


神経変性疾患と細胞死
垣塚 彰
医学の歩み 246:449-454.(2013)


ポリグルタミン病
垣塚 彰
脳神経科学イラストレイテッド ー分子・細胞から実験技術まで 327-334.(2013)



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