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| 2000〜2005 |
＜Original Papers＞
Induction of murine leukemia and lymphoma by dominant negative retinoic acid receptor alpha.
Wang, Y.A., Shen, K., Ishida, Y., Wang, Y., Kakizuka, A., & Brooks, S.C.
Mol Carcinog. 44, 252-261. 2005
ATPase activity ofp97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif.
Noguchi, M, Takata, T., Kimura, Y., Manno, A., Murakami, K., Koike, M.,Ohizumi, H., Hori, S., & Kakizuka A.
J. Biol.Chem. 280, 41332-41341. 2005
Retinoid signaling competence and RARbeta-mediated gene regulation in the developing mammalian telencephalon.
Liao, W.L., Wang, H.F., Tsai, H.C., Chambon, P., Wagner, M., Kakizuka, A., Liu, F.C.
Dev Dyn. 232:887-900, 2005
- alpha,beta -unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma.
Shiraki, T., Kamiya, N., Shiki, S., Kodama, T.S., Kakizuka, A., & Jingami,H.
J. Biol. Chem. 279:51376-51385, 2005
Physical and functional interaction between dorfin and valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders.
Ishigaki, S., Hishikawa, N., Niwa, J., Iemura, S., Natsume, T., Hori, S., Kakizuka, A., Tanaka, K., Sobue, G.
J. Biol. Chem. 279:51376-852004, 2004
A mutant ataxin-3 putative-cleavage fragment in
brain of Machado-Joseph disease patients and transgenic mice is cytotoxic
above a critical concentration.
Goti, D., Katzen S.M., Mez, J., Kurtis, N., Kiluk, J., Ben-Haiem, L., Jenkins, N. A, Copeland, N. G., Kakizuka, A., Sharp, A. H., Ross, C. A.,Mouton, P. R., & Colmer V.
J. Neuroscience 24:10266-10279, 2004
The role of pre-existing aggregates in Hsp104-dependent polyglutamine
aggregate formation and epigenetic change of yeast prions.
Kimura, Y., Koitabashi, S., Kakizuka, A., & Fujita, T.
Genes Cells 8:685-696, 2004
Alteration in thee cellular response to retinoic acid of a human acute promyelocytic leukemia cell line, UF-1, carrying a patient-deriveed mutant PML-RARa chimeric gene.
Sato, A., Imaizumi, M., Hoshi, Y., Rikiishi, T., Fujii, K., Kizaki, M., Kagechika, H., Kakizuka, A., Hayashi, Y., Iinuma K.
Leukemia Res. 9:959-967, 2004
Effective treatment of advanced solid tumors by the combination of Arsenic Trioxide and L-Buthionine-Sulfoximine.
Maeda, H., Hori, S., Ohizumi, H., Segawa, T., Kakehi, Y., Ogawa, O., & Kakizuka, A.
Cell Death Differ. 7:737-746, 2004
Molecular clearance of ataxin-3 is regulated by a mammalian E4.
Matsumoto, M., Yada, M., Hatakeyama, H., Ishimoto, H., Tanimura, T., Tsuji, S., Kakizuka, A., Kitagawa, M., Nakayama, K.I.
EMBO J. 23: 659-669, 2004
PPAR? coactivator 1?/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity in mice.
Kamei, Y., Ohizumi, H., Fujitani, Y., Nemoto, T., Tanaka, T., Takahashi, N., Kawada, T., Miyoshi, M., Ezaki, O., & Kakizuka, A.
Proc. Natl. Acad. Sci. U.S.A. 100: 12378-12383, 2003
Vacuole-creating protein in neurodegenerative diseases.
Mizuno, Y., Hori, S., Kakizuka, A. & Okamoto, K.
Neurosci. Lett. 343: 77-80, 2003
Circumvention of Chaperone Requirement for Aggregate Formation of a Short Polyglutamine Tract by the Co-expression of a Long Polyglutamine Tract.
Kimura Y., Koitabashi S., Kakizuka A. & Fujita T.
J Biol Chem. 2002 Oct 4;277(40):37536-37541
Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells.
Kobayashi T, Tanaka K, Inoue K, Kakizuka A.
J Biol Chem. 2002 Dec 6;277(49):47358-65
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.
Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A., & Ichijo, H.
Genes & Dev. 16:1345-1355, 2002
Unequal crossing-over in unique PABP2 mutations: a possible cause of oculopharyngeal muscular dystrophy.
Nakamoto, M., Nakano, S., Kawashima, S., Ihara, M., Nishimura, Y., Shinde, A., & Kakizuka, A.
Arch. Neurol. 59: 474-477, 2002
Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegenerations in Drosophila.
Higashiyama, H., Hirose, F., Yamaguchi, M., Inoue, Y., Fujikake, N., Matsukage, A., & Kakizuka, A.
Cell Death Differ. 9: 264-273, 2002
Initial process of polyglutamine aggregate formation in vivo.
Kimura, Y., Koitabashi, S., Kakizuka, A., & Fujita, T.
Genes Cells 6:887-897, 2001
Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.
Maeda, H., Hori, S., Nishitoh, H., Ichijo, H., Ogawa, O., Kakehi, Y., & Kakizuka, A.
Cancer Res. 61: 5432-5440, 2001
VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration.
Hirabayashi, M., Inoue, K., Tanaka, K., Nakadate, K., Ohsawa, Y., Kamei, Y., Popiel, A. H., Sinohara, A., Iwamatsu, A., Kimura, Y., Uchiyama, Y., Hori, S., & Kakizuka, A.
Cell Death Differ. 8: 977-984, 2001
Isolation of neuronal cells with high processing activity for the Machado-Joseph disease protein.
Yamamoto, Y., Hasegawa, H., Tanaka, K., & Kakizuka, A.
Cell Death Differ. 8: 871-873, 2001
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＜英文総説＞
Molecular analyses of Machado-Joseph disease.
Kobayashi, T., & Kakizuka, A.
Cytogenet. Genome Res. 100: 261-275, 2003
Polyglutamine diseases and molecular chaperones.
Kimura, Y., & Kakizuka, A.
IUBMB Life 55: 337-345, 2003
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＜和文総説＞
ポリグルタミン病
垣塚 彰
脳神経外科速報 15: 543〜549.(2005)
肥満のモデル動物−新たな抗肥満モデル、ERRL1マウス
亀井康富、垣塚 彰
現代医療 Vol.36 No.9 (2004)
神経変性疾患と細胞死
垣塚 彰
実験医学 Vol.22 No.11（増刊）(2004)
コンフォメーション病
垣塚 彰
細胞工学 Vol.23 No.12 (2004)
ポリグルタミン病における創薬標的
堀 清次、垣塚 彰
蛋白質・核酸・酵素 49: 1118-1121 (2004)
フォールディング病としての神経変性疾患とオルガネラ病
垣塚 彰、森 正敬
蛋白質・核酸・酵素 49: 1077-1085 (2004)
異常蛋白質センサーとしてのVCP
垣塚 彰
神経研究の進歩 48:55-62 (2004)
2000年度第３９回ベルツ賞受賞論文 Machado-Joseph病の分子解析から挑む神経変性疾患に共通する発症メカニズムの解明
垣塚 彰
最新医学 58: 331-356 (2003)
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