京都大学 垣塚研究室
TOP 垣塚教授からのメッセージ 研究内容 発表論文 メンバー紹介 スケジュール 学生募集 連絡先・アクセス リンク

発表論文

2016〜

2011〜2015

2006〜2010

2000〜2005

〜1999
2006〜2010
<Original Papers>

Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells.
Muguruma K, Nishiyama A, Ono Y, Miyawaki H, Mizuhara E, Hori S, Kakizuka A, Obata K, Yanagawa Y, Hirano T, Sasai Y.
Nat Neurosci. 2010 Sep 12.


Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia.
Manno A, Noguchi M, Fukushi J, Motohashi Y, Kakizuka A.
Genes Cells. 2010 Jul 5.


Valosin-containing protein (VCP) in novel feedback machinery between abnormal protein accumulation and transcriptional suppression.
Koike M, Fukushi J, Ichinohe Y, Higashimae N, Fujishiro M, Sasaki C, Yamaguchi M, Uchihara T, Yagishita S, Ohizumi H, Hori S, Kakizuka A.
J Biol Chem. 2010 Apr 21.


Maintaining ATP levels via the suppression of PERK-mediated rRNA synthesis at ER stress.
Okamoto A, Koike M, Yasuda K, Kakizuka A.
Biochem Biophys Res Commun. 2010 Mar 26;394(1):42-7.


Glucosamine induces autophagy via an mTOR-independent pathway.
Shintani T, Yamazaki F, Katoh T, Umekawa M, Matahira Y, Hori S, Kakizuka A, Totani K, Yamamoto K, Ashida H.
Biochem Biophys Res Commun. 2010 Jan 22;391(4):1775-9.


Listeria monocytogenes ActA-mediated escape from autophagic recognition.
Yoshikawa Y, Ogawa M, Hain T, Yoshida M, Fukumatsu M, Kim M, Mimuro H, Nakagawa I, Yanagawa T, Ishii T, Kakizuka A, Sztul E, Chakraborty T, Sasakawa C.
Nat Cell Biol. 2009 Oct;11(10):1233-40.


An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis.
Kimura Y, Yashiroda H, Kudo T, Koitabashi S, Murata S, Kakizuka A, Tanaka K.
Cell. 2009 May 1;137(3):549-59.


p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation.
Mori-Konya C, Kato N, Maeda R, Yasuda K, Higashimae N, Noguchi M, Koike M, Kimura Y, Ohizumi H, Hori S, Kakizuka A.
Genes Cells. 2009 Apr;14(4):483-97.


Direct detection of the interaction between recombinant soluble extracellular regions in the heterodimeric metabotropic gamma -aminobutyric acid receptor.
Nomura, R., Suzuki, Y., Kakizuka, A., Jingami, H.
J Biol Chem. Dec 28; [Epub ahead of print] 2007


Involvement of valosin-containing protein (VCP)/p97 in the formation and clearance of abnormal protein aggregates.
Kobayashi T, Manno A, Kakizuka A.
Genes Cells. Jul;12(7):889-901. 2007


In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia.
Matsushita H, Scaglioni PP, Bhaumik M, Rego EM, Cai LF, Majid SM, Miyachi H, Kakizuka A, MIller WH Jr, Pandolfi PP.
J Exp Med. Apr 17;203(4):821-8. 2006


Dominant-negative effect of mutant valosin-containing protein in aggresome formation.
Kitami, M.I., Kitami, T., Nagahama, M., Tagaya, M., Hori, S., Kakizuka, A.,Mizuno, Y., & Hattori, N.
FEBS Lett. 580, 474-478. 2006


<英文総説>

Roles of VCP in human neurodegenerative disorders.
Kakizuka, A.
Biochem Soc Trans. 2008 Feb;36(Pt 1):105-8. Review.


<和文総説>

神経変性疾患にかかわる蛋白質の種々の修飾
垣塚 彰・小池雅昭
蛋白質 核酸 酵素 Vol.52 No.7 (2007)


神経変性疾患と核
垣塚 彰
細胞核の世界‐ダイナミクスから病態まで(2006)


ポリグルタミン病
垣塚 彰
脳神経科学イラストレイテッド(羊土社) 312〜319.(2006)


神経変性疾患と小胞体ストレス
野口昌克、垣塚 彰
医学のあゆみ 216:4033〜4039. (2006)



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